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(Continued from page 1) In the wake of this
seminal work, 1,086 published studies have since examined CLA’s role in
cancer, immune function, oxidative stress, atherosclerosis, lipid and fatty
acids metabolism, bone density, obesity, and diabetes (Figure 2 – page
three and http://www.wisc.edu/fri/clarefs.htm).
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The scientific interest
in CLA has grown exponentially over the last three years. In fact, there
were more peer-reviewed publications on CLA in 2003 than in all the years
from 1979 to 1998. An average of approximately five CLA research articles
are published per week. All of this information should make it a relatively
simple matter to understand the role of CLA in human health. In fact, just
the opposite is true. At this time, there are numerous apparent inconsistencies
in the results of all of this research. The principle reason for this is
the number of variables inherent in any single study, making it difficult
to compare results from one publication to another.
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can differ (i) in the relative amounts of CLA isomers used, (ii) in the
form of the isomer, free fatty acid or triglyceride, (iii) in the model
used, in vitro or in vivo, (iv) in the genetics of the cell lines or animals
used, and (v) in the subpopulation studied in clinical intervention trials.
All of these factors contribute to the difficulty of interpreting the enormous
amount of information on CLA. However daunting the task, this article will
try to organize and interpret the body of CLA research and present an overview
of the potential for CLA supplementation in HIV.
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