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Henrik Friis,
Pernille Kaestel, Astrid Iversen and Susanne Bugel discuss selenium and
HIV infection in Chapter Nine. The authors follow the format of previous
chapters reviewing the historical background of selenium, metabolism and
biological functions, assessment of selenium status, dietary requirements
and food sources. Host defense and the role of selenium in the development
of nutrition-infection interactions covers Keshan disease, the coxsackievirus-mouse
model and other infections. A few pages are devoted to selenium status
in HIV infection and selenium and HIV progression, which includes a review
of both clinical and laboratory studies. As with other authors, Friis,
Kaestel, Iversen and Bugel disclose that although selenium deficiency may
be low in HIV-positive people and impairs the antioxidant defense and immune
system, studies are needed to clarify the role of selenium in HIV progression
and transmission.
Chapter 10, Micronutrients
in the Case Management of HIV Infection, is written by Heloise Buys and
Gregory Hussey both at the University of Cape Town in South Africa. Noting
that micronutrient deficiencies occur in people with HIV they review contributing
factors, impact on other infections and the impact of deficiencies on HIV
morbidity and mortality. The authors discuss micronutrient interventions
and highlight both selected intervention and cohort studies that assessed
the effect of micronutrient supplements in HIV-positive people. After discussing
case management strategies the authors conclude the chapter with a review
of unresolved issues pertaining to micronutrient deficiencies in people
with HIV.
Henrik Friis, Exnevia
Gomo and Kim Michaelsen wrote the final chapter of the book, which deals
with micronutrient interventions and HIV. The authors review the importance
of micronutrients to HIV infection noting key information on the micronutrients
covered in previous chapters of the book. Multiple micronutrient deficiencies
and interactions and the determinants of micronutrient deficiencies are
discussed along with micronutrient interventions. As noted earlier in the
book, Friis, Gomo and Michaelsen review research priorities and conclude
that public health policy and programs addressing micronutrient interventions
should be developed.
Micronutrients & HIV
Infection is not written for a general audience and should be most useful
to researchers and clinicians interested in learning about micronutrients
and HIV infection. Numerous references from a variety of countries offer
additional resources to help the reader extend their knowledge of research
on the micronutrients covered in the book.
2002, hardcover bound,
272 pages, $99.95 + S&H, CRC Press,
Boca Raton, FL 800/272-7737.
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