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Contraindications:
Hypersensitivity to pravastatin or any component of the formulation, active
liver disease, unexplained persistent elevations of serum transaminases;
pregnancy; and breastfeeding.
Warnings/Precautions:
To
lessen the possibility of myopathy, patients should not take pravastatin
with high dose niacin. Use with caution in patients who consume large amounts
of ethanol or have a history of liver disease. May elevate aminotransferases;
liver function tests (LFT’s) should be performed before therapy, prior
to elevation of dose, and periodically thereafter. Can also cause myalgia
and rhabdomyolysis. Risk is increased with concurrent use of clarithromycin,
danazol, diazepam, fluvoxamine, indinavir, nefazodone, nelfinavir, ritonavir,
verapamil, troleeaandomycin, cyclosporine, fibric acid derivatives, erythromycin,
niacin, or azole antifungals.
Adverse Reactions:
Abdominal cramps, chest pain, diarrhea, dyspepsia, fatigue, heartburn,
myalgia, nausea, vomiting.
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