PAGE 18
HIV NUTRITION UPDATE
VOLUME 7, ISSUE 2

(Return to page 17)
Drug Induced Nutrient
Depletion Handbook

Drug Induced Nutrient Depletion Handbook (2nd edition - ISBN 1-930598-45-9) by Ross Pelton, RPh, PhD, CCN and others is meant to increase the awareness of health professionals on the subject of nutrient depletion caused by drugs. The book is divided into eight sections including an introduction and explanation of how to use the book, which is in Section One.

Section Two comprises half the pages of the book and consists of drug monographs in alphabetical order by generic name. Each monograph includes: U.S. Brand Names, Synonyms, Pharmacologic class of the drug, Nutrient(s) Depleted, Scientific basis for including the depletion and referrals to the studies and abstracts that provide evidence of the depletion. Each drug is listed separately including common combination drugs. 

Section Three is an alphabetical listing of nutrients and drugs that deplete that nutrient along with page number referrals back to the drug monographs. Monographs are in alphabetical order in Section Four and include: available compounds, effects of depletion, overview, biological function and effect, side effects and toxicity, RDA, Dosage Range, Dietary Sources and forms available.
 


In Section Five the authors present 518 scientific abstracts that document the drug-induced nutrient depletion. The abstracts are numbered and grouped by pharmacologic class of drugs, i.e., anticonvulsants, antivirals, cardiovascular drugs, etc. Section Six is an appendix that summarizes much of the information in Section Two in table form. It also includes a small section on herb-drug and food-drug interactions. The alphabetical index by drug names is in Section Seven and includes both generic and U.S. brand names and nutrient names.

This book is very useful as a research tool. It is in an easy to use form with page number referrals, which allows the reader to move smoothly from one section to another. Readers, however, must read all abstracts, which include both positive and negative studies. It is important to evaluate depletions listed in Section Two before presenting them as a possible effect of the drug. Some depletions listed in Section Two are based only on animal models and others on just a few case reports. Thus, the health professional may not feel that this can be extrapolated to his/her patient(s).

Used along with other informational sources that focus on common drug side effects and publications that focus on the effect of nutrients on drugs, this book is a very useful addition to a clinician’s library of drug information. 

2001, softcover bound, 4” x 7”, 591 pages, $29.95 + S&H, Lexi-Comp, Inc., Hudson, OH  800/837-5394.

Reviewed by: Zaneta M. Pronsky, MS, RD, FADA,  Author/ Consultant, Food Medication Interactions in Birchrunville, PA.
 


 
 

 
 
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9/23/2002